Bigbug The problem with having the mail server do auto replies would mean that all emails to the monitored mailbox would get a reply, not just the ones that are flagged and ticket creation failed.
In my scenario, if current clients email support@msp.com, everything works fine and a ticket is created. If a new or unknown customer emails support@msp.com, the email is "flagged" but there is no immediate notification to either myself or the customer.
I understand the logic as to why the Devs don't want email spam creating tickets and adding clutter to the database, but to manually check the Inbox (in my case a separate Google Workspace/Gmail account) isn't very practical either.